The rapid expansion of tick-borne illness in the Americas and Europe poses great challenges for the prevention and treatment of these diseases, in both humans and animals. Though Lyme Disease continues to be the predominant disease (with estimates of as many as 300,000 new cases every year in the US), new and emerging illnesses are increasingly reported. The cost for treatment of these diseases continues to rise. As humans and animals spend more time in wooded areas, the threat becomes even more urgent. This conference will address the newest science in the pathogenesis of these diseases, along with the latest research into prevention and treatment of these crippling illnesses.